Notice of 35th Annual General Meeting of Shareholders

Dear Shareholders,

Celltrion announces the 35th Annual General Shareholders’ Meeting.

 

Notice of 35th Annual General Meeting of Shareholders

2026 Annual Meeting of Shareholders

 

1.    Date and Time: March 24, 2026 10:00a.m. KST

 

2.   Venue: Grand Ballroom, Songdo Convensia (123, Central-ro, Yeonsu-gu, Incheon, Republic of Korea)

 

3.    Agendas

       ■ Matters to Report

        - Report on Audit and Business for Fiscal Year 2025

        - Report on Internal Audit Management for Fiscal Year 2025

       ■ Matters for Approval

       - Approval of Audited Financial Statements for Fiscal Year 2025
       - Approval of Partial Amendments to the Articles of Incorporation
       - Election of Directors 
       - Election of Outside Directors for Audit Committee Members
       - Election of Audit Committee Members
       - Approval of the Director Remuneration Limit

       - Approval of the Plan for Treasury Share Holding and Disposition and Cancellation of Treasury Shares

 

For detailed information, please visit:
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Letter to Shareholders [U.S. Manufacturing Operations and Tariff Risk Position]

Dear Valued Shareholders,

 

To address market concerns arising from recent references to changes in U.S. government tariff policies, we would like to share with our shareholders the current operational status of the Branchburg facility and our forward plans as follows.

 

Initiation of CMO Production and Validation for In-House Product Manufacturing

 

Following the successful completion of the acquisition of the former Eli Lilly facility late last year, we finalized a comprehensive inspection of the entire site and completed all preparations for full-scale operations by the end of January this year. Based on these efforts, we commenced full-scale production of Lilly CMO products across all lines beginning in February, thereby demonstrating the operational efficiency of our U.S. manufacturing facility.

 

In parallel, Celltrion has initiated validation procedures required for the manufacturing of its own products. By integrating local manufacturing with its direct commercial network, we plan to establish a fully integrated system capable of supplying locally manufactured products to the U.S. market in due course.

 

Structural Mitigation of Tariff Risks and Completion of Preemptive Measures

 

Celltrion has completed all necessary measures to ensure that its business operations remain unaffected, regardless of how future U.S. tariff issues may unfold.

 

  • Short-term Response: Sales will continue without tariff impact through the utilization of approximately two years of inventory already positioned within the United States.
  • Mid- to long-term Response: Direct supply of products from the Branchburg manufacturing facility will enable the operation of a production-and-sales system that is fully insulated from tariff-related issues.

 

In conclusion, despite the U.S. Supreme Court’s ruling invalidating reciprocal tariffs and the potential for future changes in tariff policy under the Trump administration, we have established a structurally resilient local production and supply system, ensuring that its operations remain unaffected by tariff-related uncertainties.

 

Celltrion remains focused on closely monitoring local market conditions and making every effort to safeguard shareholder value. We sincerely appreciate our shareholders’ continued trust and support. 

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News

Celltrion announces U.S. availability of AVTOZMA® (tocilizumab-anoh) subcutaneous (SC) formulation

AVTOZMA® (tocilizumab-anoh) is among the first wave of tocilizumab biosimilars with both intravenous (IV) and subcutaneous (SC) formulations approved and commercially available in the United StatesThe launch of AVTOZMA SC further diversifies Celltrion's immunology portfolio beyond TNF-alpha and IL-12/23 inhibitors providing a broader range of treatment solutions for immune-mediated inflammatory diseases INCHEON, South Korea, March 16, 2026 - Celltrion, Inc. today announced that AVTOZMA® (tocilizumab-anoh) subcutaneous (SC) formulation is now commercially available to patients in the United States. With this launch, Celltrion's AVTOZMA becomes one of the first tocilizumab biosimilars to have both an intravenous (IV) and a SC formulation approved by the U.S. Food and Drug Administration (FDA) and available on the U.S. market. "The introduction of AVTOZMA SC is a pivotal moment for Celltrion, underscoring our dedication to delivering effective, accessible and user-friendly therapies for patients with chronic inflammatory diseases," said Thomas Nusbickel, Chief Commercial Officer of Celltrion USA. "By offering both IV and SC formulations, we aim to provide patients and healthcare professionals with greater flexibility in treatment decisions, while continuing to broaden our immunology portfolio with therapies that address diverse inflammatory pathways." The SC formulation of AVTOZMA is indicated for the treatment of rheumatoid arthritis (RA), giant cell arteritis (GCA), polyarticular juvenile idiopathic arthritis (PJIA) and systemic juvenile idiopathic arthritis (SJIA). AVTOZMA SC is available in a 162 mg/0.9 mL solution for injection in a single-dose prefilled syringe or a single-dose prefilled autoinjector, allowing patients the flexibility and convenience of administering their treatment at home. [1] Celltrion provides support to U.S. patients prescribed AVTOZMA through its patient support program, Celltrion CONNECT™. Celltrion CONNECT™ offers tailored support to its patients and caregivers with a full range of services including injection training, reimbursement assistance and educational resources to patients and healthcare professionals. Notes to Editors: About AVTOZMA® (CT-P47, tocilizumab-anoh)AVTOZMA® (tocilizumab-anoh), containing the active ingredient tocilizumab, is a recombinant humanized monoclonal antibody that acts as an interleukin 6 (IL-6) receptor antagonist. Based on data from the global Phase III clinical trial designed to evaluate the efficacy, pharmacokinetics (PK), safety, and immunogenicity of CT-P47 compared to reference tocilizumab, AVTOZMA received approval from the U.S. Food and Drug Administration (FDA) and European Commission (EC) in January and February 2025, respectively. In July 2025, the FDA approved an additional indication for the intravenous (IV) formulation of AVTOZMA for the treatment of cytokine release syndrome (CRS) in adult and pediatric patients aged two years and older. INDICATION AVTOZMA® (tocilizumab-anoh) IV is an interleukin-6 (IL-6) receptor antagonist indicated for treatment of: Rheumatoid Arthritis (RA): Adult patients with moderately to severely active RA who have had an inadequate response to one or more Disease-Modifying Anti-Rheumatic Drugs (DMARDs).Giant Cell Arteritis (GCA): Adult patients with GCA.Polyarticular Juvenile Idiopathic Arthritis (pJIA): Patients 2+ years-old with active pJIA.Systemic Juvenile Idiopathic Arthritis (sJIA): Patients 2+ years-old with active sJIA.Cytokine Release Syndrome (CRS): Adults and pediatric patients 2+ years-old with chimeric antigen receptor (CAR) T cell-induced severe or life-threatening cytokine release syndromeCOVID-19: Hospitalized adult patients with COVID-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO). AVTOZMA® (tocilizumab-anoh) SC is an interleukin-6 (IL-6) receptor antagonist indicated for treatment of: Rheumatoid Arthritis (RA): Adult patients with moderately to severely active RA who have had an inadequate response to one or more Disease-Modifying Anti-Rheumatic Drugs (DMARDs).Giant Cell Arteritis (GCA): Adult patients with GCA.Polyarticular Juvenile Idiopathic Arthritis (pJIA): Patients 2+ years-old with active pJIA.Systemic Juvenile Idiopathic Arthritis (sJIA): Patients 2+ years-old with active sJIA. IMPORTANT SAFETY INFORMATION WARNING: RISK OF SERIOUS INFECTIONS AVTOZMA® and other tocilizumab products may increase the risk of serious infections, potentially leading to hospitalization or death, especially in patients using concurrent immunosuppressants. If a serious infection develops, interrupt AVTOZMA until the infection is controlled. Reported infections include: Active tuberculosis (TB) which may present with pulmonary or extrapulmonary disease. Test for latent TB before and during treatment (except in COVID-19 patients) and treat latent infections before starting AVTOZMA.Invasive fungal infections: Such as candidiasis, aspergillosis, and pneumocystis, may present as disseminated rather than localized disease.Opportunistic infections, including bacterial, viral and other opportunistic pathogens. Monitor patients for signs of infection, including TB, during and after AVTOZMA treatment.Contraindications: Known hypersensitivity to tocilizumab products.Serious Infections. Serious and sometimes fatal infections have been reported with AVTOZMA. Do not use during active infections, including localized infections. Discontinue AVTOZMA if a serious infection occurs and resume only once controlled. Gastrointestinal (GI) Perforation. Gastrointestinal perforations, often linked to diverticulitis, have been reported with tocilizumab. Use AVTOZMA cautiously in high-risk patients and promptly evaluate new abdominal symptoms for early detection and management. Hepatoxicity. Monitor for hepatic injury signs. Avoid AVTOZMA if ALT/ AST >1.5x ULN (RA/GCA) or >10x ULN (COVID-19); discontinue if ALT/AST >5x ULN or symptoms of liver disease develop. Changes in Laboratory Parameters. Monitor neutrophils, platelets, liver enzymes, and lipids due to potential treatment-related changes; avoid initiating AVTOZMA in patients with critically low ANC or platelet counts. Immunosuppression. The impact of AVTOZMA on malignancy development is unknown, but it may increase risk as an immunosuppressant. Hypersensitivity Reactions, including anaphylaxis, and death, have occurred; administer IV infusions with anaphylaxis management support, discontinue permanently if reactions occur, and avoid use in patients with known hypersensitivity. Demyelinating Disorders. The impact of tocilizumab on demyelinating disorders is unknown, but rare cases were reported; monitor symptoms and use caution with preexisting or recent disorders. Active Hepatic Disease and Hepatic Impairment. Treatment with AVTOZMA is not recommended. Live Vaccines. Avoid concurrent use with AVTOZMA. Adverse Reactions (≥5%) include upper respiratory tract infections, nasopharyngitis, headache, hypertension, elevated ALT, and injection site reactions. For more information, see FullPrescribing Information. About Celltrion Celltrion is a leading biopharmaceutical company that specializes in researching, developing, manufacturing, marketing and sales of innovative therapeutics that improve people's lives worldwide. Celltrion is a pioneer in the biosimilar space, having launched the world's first monoclonal antibody biosimilar. Our global pharmaceutical portfolio addresses a range of therapeutic areas including immunology, oncology, hematology, ophthalmology and endocrinology. Beyond biosimilar products, we are committed to advancing our pipeline with novel drugs to push the boundaries of scientific innovation and deliver quality medicines. For more information, please visit our website www.celltrion.com/en-us and stay updated with our latest news and events on our social media - LinkedIn, Instagram, X, and Facebook. About Celltrion USA Celltrion USA is Celltrion's U.S. subsidiary established in 2018. Headquartered in New Jersey, Celltrion USA is committed to expanding access to innovative biologics to improve care for U.S. patients. Celltrion's FDA-approved biosimilar products in immunology, oncology, hematology, and endocrinology include: INFLECTRA® (infliximab-dyyb), TRUXIMA® (rituximab-abbs), HERZUMA® (trastuzumab-pkrb), VEGZELMA® (bevacizumab-adcd), YUFLYMA®(adalimumab-aaty), AVTOZMA® (tocilizumab-anho), STEQEYMA® (Ustekinumab-stba) STOBOCLO® (denosumab-bmwo), OSENVELT® (denosumab-bmwo), and OMLYCLO® (omalizumab-igec), as well as the novel biologic ZYMFENTRA® (infliximab-dyyb). Celltrion USA will continue to leverage Celltrion's unique heritage in biotechnology, supply chain excellence and best-in-class sales capabilities to improve access to high-quality biopharmaceuticals for U.S. patients. For more information, please visit www.celltrionusa.com and stay updated with our latest news and events on our social media - LinkedIn. FORWARD-LOOKING STATEMENT Certain information set forth in this press release contains statements related to our future business and financial performance and future events or developments involving Celltrion Inc. and its subsidiaries that may constitute forward-looking statements, under pertinent securities laws. This press release contains forward looking statements. These statements may be also identified by words such as "prepares", "hopes to", "upcoming", "plans to", "aims to", "to be launched", "is preparing", "once gained", "could", "with the aim of", "may", "once identified", "will", "working towards", "is due", "become available", "has potential to", "anticipates", the negative of these words or such other variations thereon or comparable terminology. In addition, our representatives may make oral forward-looking statements. Such statements are based on the current expectations and certain assumptions of Celltrion Inc. and its subsidiaries' management, of which many are beyond its control. Forward-looking statements are provided to allow potential investors the opportunity to understand management's beliefs and opinions in respect of the future so that they may use such beliefs and opinions as one factor in evaluating an investment. These statements are not guarantees of future performance and undue reliance should not be placed on them. Such forward-looking statements necessarily involve known and unknown risks and uncertainties associated with the company's business, including the risk factors disclosed in its Annual Report and/or Quarterly Reports, which may cause actual performance and financial results in future periods to differ materially from any projections of future performance or results expressed or implied by such statements. Celltrion Inc. and its subsidiaries undertake no obligation to update forward-looking statements if circumstances or management's estimates or opinions should change except as required by applicable securities laws. Trademarks AVTOZMA® is a registered trademark of Celltrion Inc.ACTEMRA® is a registered trademark of Chugai Pharmaceutical Co., Ltd.  References[1] AVTOZMA U.S. prescribing information (2025)For further information please contact: Brendi Bluittbbluitt@jpa.com  +1 202-545-7722SOURCE Celltrion

2026
03
17
Celltrion signs supply agreement with a global biopharma worth up to KRW 375.4 billion, reflecting recognition of product quality and manufacturing productivity, and accelerating CDMO growth

- Celltrion confirms a KRW 294.9 billion supply agreement, which may expand to KRW 375.4 billion, subject to mutual agreement.- Consecutive CMO wins, including Eli Lilly, push cumulative order backlog beyond KRW 1 trillion, supporting future revenue growth.- Growing requests for CDMO partnerships and increasing production of Celltrion’s own products are driving the need for additional manufacturing capacity. INCHEON, South Korea – Celltrion announced today that it has signed a contract manufacturing (CMO) agreement with a global pharmaceutical company for the supply of drug substance. The counterparty remains undisclosed to ensure business confidentiality. Under the agreement, Celltrion will supply drug substance for three years from 2027 through 2029. The contract value is approximately KRW 294.9 billion and may expand to KRW 375.4 billion, subject to mutual agreement.  Celltrion plans to complete production arrangements early to ensure stable delivery. Strong product quality leads to contracts and accelerates CDMO business growth Celltrion has consistently demonstrated high manufacturing quality, reliable supply capabilities, and efficient production operations in supplying biologics. The latest contract reflects strong recognition of Celltrion’s manufacturing quality and stable supply system that meets global standards. Celltrion’s global CMO business has been expanding rapidly since the company announced plans to strengthen the business last year. Earlier this year, Celltrion signed a KRW 678.7 billion[1] CMO contract with Eli Lilly, and with the addition of this agreement, the company’s cumulative CMO order backlog surpassed KRW 1 trillion within the first quarter of the year. These contracts with global pharmaceutical companies demonstrate growing recognition of Celltrion’s manufacturing technology and global supply capabilities in the market. Celltrion to review additional capacity expansion amid growing global CDMO demand As demand for CDMO partnerships from global pharmaceutical companies continues to grow, Celltrion is strengthening its global sales and project management capabilities through its subsidiary Celltrion BioSolutions to further streamline its CMO business operations. Celltrion differentiates its CMO business by offering technology-driven service models. One such service is its “formulation conversion CMO,” which provides partners with the company’s accumulated subcutaneous (SC) formulation technologies developed through products such as Remsima SC (marketed as Zymfentra in the United States) and Herzuma SC. Celltrion aims to move beyond traditional contract manufacturing to provide high-value CMO services that enhance partners’ product competitiveness, and will accelerate efforts to expand production capacity and infrastructure to support this strategy. In addition, as the global biopharmaceutical market continues to expand and pharmaceutical companies increasingly seek reliable manufacturing partners, interest in Celltrion’s manufacturing capabilities is also steadily growing. Celltrion currently has a total manufacturing capacity of 316,000 liters, including facilities in Songdo, Korea (Plants 1, 2 and 3 with a combined capacity of 250,000 liters) and its facility in Branchburg, New Jersey (66,000 liters). However, global sales of Celltrion’s own products, including Zymfentra, are expected to expand alongside the addition of new pipeline products. Consequently, a significant portion of existing production capacity is likely to be allocated to the manufacturing of Celltrion’s own products. At the same time, rapidly increasing CDMO demand from global pharmaceutical companies is further raising the need for additional manufacturing capacity in the mid to long term. Taking these factors into account, Celltrion is reviewing additional manufacturing facilities both domestically and overseas to ensure sufficient infrastructure and support growing global CDMO demand. “This large-scale CMO agreement once again shows that Celltrion’s manufacturing quality and supply capabilities are recognized in the global market,” a Celltrion official said. “Considering the need to expand manufacturing for our own products, along with the growth of the CDMO business and increasing global demand, we plan to actively pursue additional manufacturing capacity to support future growth.” [1] Initial base exchange rate (December 31, 2025): USD/KRW $1 = KRW 1,434.90.

2026
03
17
Celltrion set to benefit from global biosimilar regulatory streamlining, driving economies of scale from development to manufacturing and direct sales

- The FDA’s move to streamline PK testing and expand the use of non-U.S.-licensed comparator products is expected to reduce total clinical development costs by up to 25%.- Leveraging its internalized capabilities, Celltrion plans to expand its portfolio to include products targeting small and mid-sized markets, further strengthening economies of scale.- Celltrion plans to expand its biosimilar portfolio to 41 products by 2038, with the number of products under development expected to increase rapidly.- With capabilities spanning development, manufacturing and direct sales, Celltrion is well positioned to benefit from the regulatory changes. INCHEON, South Korea – Celltrion announced today that it will immediately incorporate newly announced global regulatory updates aimed at streamlining biosimilar development into its ongoing pipeline programs, with the goal of significantly reducing development costs and timelines. The company expects that the latest policy changes, combined with its expanding multi-product portfolio, will serve as a catalyst for achieving unprecedented economies of scale across its biosimilar business.The U.S. Food and Drug Administration (FDA) recently announced the fourth revision of the “New and Revised Draft Q&As on Biosimilar Development and the BPCI Act,” aimed at streamlining the biosimilar development process. The revised draft guidance recommends streamlining clinical pharmacokinetic (PK) testing typically conducted during Phase 1 trials when scientifically justified. One of the most notable revisions involves the relaxation of comparator product requirements. Previously, biosimilar developers seeking approval in the United States were required to conduct direct PK comparison studies using a U.S.-licensed reference product. Under the updated guidance, however, comparative clinical data generated using a comparator product approved outside the United States may also be accepted to support a demonstration of biosimilarity. This change is expected to significantly reduce development costs, particularly in the immuno-oncology field where reference biologics are extremely expensive. Celltrion maintains strong competitiveness in this area with multiple products currently under development. The company therefore expects this measure alone could reduce overall clinical development costs by up to 25%. When combined with the FDA’s draft guidance issued in October last year aimed at reducing or waiving certain Phase 3 clinical studies, the overall cost-saving effect across the development process is expected to increase further. Although the revised guidance remains in draft form, Celltrion believes it reflects the FDA’s latest perspective, and plans to immediately apply the updated regulatory approach to its ongoing development programs to significantly shorten development timelines and reduce costs. Even prior to the regulatory changes, Celltrion has maintained industry-leading cost competitiveness through its integrated capabilities spanning development, manufacturing and direct sales. With a direct sales network already established across most key markets and additional savings expected from reduced clinical and comparator product costs, this cost advantage is expected to strengthen further. Celltrion also views the regulatory streamlining not merely as a cost-reducing measure, but as a strategic lever to achieve larger economies of scale across its entire product portfolio. By reinvesting resources saved through streamlined clinical requirements into additional pipeline development, the company expects to accelerate the expansion of its mid- to long-term product portfolio, including products targeting small and mid-sized markets that were previously difficult to pursue due to high clinical development costs. Streamlined regulatory requirements for clinical data and approval procedures are elevating the importance of expertise in antibody analytics, comparability assessment and process development, thereby favorably positioning companies like Celltrion who possess robust early-stage development capabilities. Beyond the 11 biosimilar products currently marketed globally, Celltrion plans to expand its portfolio to 41 products by 2038. Through this expansion, the company expects to target a global market projected to exceed KRW 400 trillion, more than four times larger than the KRW 85 trillion addressable market recorded last year. Celltrion believes that the recent global trend toward regulatory streamlining could support a further expansion of its product development plans. Key disclosed pipeline programs include CT-P53 (Ocrevus biosimilar), CT-P55 (Cosentyx biosimilar), CT-P52 (Taltz biosimilar) in autoimmune diseases, as well as CT-P51 (Keytruda biosimilar) and CT-P44 (Darzalex biosimilar) in oncology. In addition, more than 20 additional pipeline programs remain undisclosed. Notably, Celltrion recently reduced Phase 3 clinical trial enrollment for CT-P55 from 375 patients to 153, reflecting the impact of regulatory streamlining and suggesting the potential for faster development timelines. “The global trend toward regulatory streamlining presents a significant opportunity for Celltrion, which possesses strong early-stage development capabilities, large-scale manufacturing capacity and a global direct sales network,” a Celltrion official said. “By reinvesting the cost savings to further expand our pipeline, we aim to achieve greater economies of scale and strengthen our cost competitiveness as we continue advancing toward becoming a leading global biopharmaceutical company.”

2026
03
13
Celltrion launches Remsima IV liquid formulation in Europe, securing new competitiveness to lead the global infliximab market

- Early performance demonstrated with national tender wins in Norway and Denmark… Secured 35% share of the IV market in the Netherlands- The world’s first and only infliximab liquid formulation… Patent registrations completed across most European countries including the EU5- Continued field-friendly marketing activities through formulation innovation reflecting clinical needs… Enhancing brand value- The world’s first and only full infliximab portfolio of IV and SC formulations… “Will continue innovation in biosimilar products” [March 11, 2026, KST] Celltrion today announced the European launch of the liquid formulation of Remsima (infliximab), strengthening its leadership in the infliximab market. The infliximab liquid formulation is uniquely held by Celltrion globally and is supported by registered patents. As a newly introduced formulation reflecting clinical needs, it is expected to further reinforce Remsima’s influence through enhanced product competitiveness and expanded market impact. Celltrion’s Nordic affiliate achieved early success by securing contracts with the Remsima intravenous (IV) liquid formulation in infliximab national tenders held in Denmark and Norway. Following the European approval of the Remsima IV liquid formulation in November last year, the local affiliate had prepared in advance to ensure product distribution through key national tenders. As a result, sales in Norway began immediately after the tender award, with supply planned through January 2028. Through this, the product is expected to secure approximately 35% share of the infliximab IV market in Norway. The Remsima liquid formulation expands treatment options by reflecting clinical needs, alongside the existing Remsima IV (100 mg lyophilized formulation) and Remsima SC. In European clinical settings, there has been continuous demand for a multi-dose liquid formulation that enables more efficient storage and management while reducing the complexity of the preparation process. Reflecting these needs, Celltrion has introduced the Remsima 350 mg liquid formulation, while continuing to strengthen field-focused sales and marketing activities. With the field-friendly Remsima liquid formulation, healthcare institutions are expected to benefit from administrative and cost efficiencies, further strengthening the competitiveness of the Remsima portfolio. Compared with the lyophilized formulation, the liquid formulation can reduce preparation time by approximately 50%, while lowering labor and consumable costs by around 20% during drug preparation. In addition, storage space and related storage costs can be reduced by up to 70%, generating strong interest across Europe from the early stage of launch. The recent national tender award in Norway also reflects recognition of these advantages and is expected to serve as a new competitive strength for Remsima in Europe, where tender markets represent a significant portion of demand. Celltrion has also filed patents for the Remsima liquid formulation and has completed patent registrations in most European countries, including the EU5 markets such as the UK, Germany and France. As Remsima is the only infliximab product available in a liquid formulation, its differentiated competitiveness is expected to further strengthen its influence in the infliximab market. Following the development and commercialization of the world’s first infliximab SC formulation, Celltrion has now secured the IV liquid formulation, becoming the only company globally to establish a full portfolio of infliximab IV (lyophilized and liquid) and SC formulations. Based on this, the company aims to further strengthen brand trust in Remsima in the infliximab market, expand prescriptions across both Remsima IV and SC, and enhance profitability. In addition, Celltrion plans to continue product innovation reflecting clinical needs while reinforcing its differentiated corporate image with unique competitiveness in the biosimilar market. Starting with the Nordic region, Celltrion plans to expand the launch of the Remsima liquid formulation across Europe this year, including France, the Netherlands and the Czech Republic, further strengthening its leadership in the infliximab market. According to pharmaceutical market research firm IQVIA, the Remsima portfolio (IV and SC) maintained the No.1 position in infliximab prescriptions in Europe with a 68% market share as of Q3 last year. Based on the strengthened Remsima portfolio with a full formulation lineup, Celltrion plans to continue strengthening its market position while addressing diverse clinical needs. “As trust in Celltrion continues to build in the European biosimilar market, the Remsima liquid formulation reflects clinical needs and has demonstrated its competitiveness by securing tender wins immediately after launch," said Seung-doo Baek, Head of Celltrion’s Nordic affiliate. "Going forward, we will continue field-focused sales and marketing activities to provide better treatment options for patients and healthcare professionals in Europe while further expanding prescriptions.”

2026
03
11
Celltrion to expand treasury share cancellation to 9.11 million shares: Prioritizing shareholder value amid heightened market uncertainty

- Celltrion plans to expand treasury share cancellation to 9.11 million shares by adding 3 million shares originally reserved for employee compensation to the previously announced 6.11 million shares.- The total treasury share cancellation amounts to KRW 1.9268 trillion, representing the cancellation of 74% of the company’s total treasury shares to enhance shareholder value.- The decision reflects a proactive response to market volatility amid rising geopolitical risks and uncertainties, while reaffirming the company’s commitment to prioritizing shareholder value.- “We are prioritizing shareholder value amid heightened uncertainties and will make every effort to achieve this year’s revenue target of KRW 5.3 trillion,” a Celltrion official said. INCHEON, South Korea – Celltrion announced today that it has decided to expand treasury share cancellation to approximately 9.11 million shares and disclosed a revision to the agenda for its upcoming annual general meeting of shareholders. Based on the closing price on March 5, the total value of the shares to be cancelled amounts to approximately KRW 1.9268 trillion[1].In the agenda for the 35th annual general meeting of shareholders previously disclosed, Celltrion proposed a resolution titled “Approval of Treasury Share Holding and Disposal Plan and Cancellation,” which included the cancellation of approximately 6.11 million treasury shares, excluding shares reserved for stock option compensation. The approximately 3 million shares excluded from cancellation had been retained to fulfill stock option grants already awarded to certain employees. Through this latest disclosure, Celltrion proposed revising the agenda to include these stock option-related treasury shares as well, thereby increasing the total cancellation volume to approximately 9.11 million shares. Employee stock option compensation will be managed through new share issuances. However, as the treasury shares will be cancelled first and new shares issued afterward, the company expects no impact on the total number of shares outstanding. The approximately 9.11 million shares to be cancelled represent about 74% of the total treasury shares held by Celltrion. The remaining 3.23 million shares, equivalent to about 26%, will be utilized to support future growth initiatives. Celltrion’s decision to cancel nearly three quarters of its treasury shares reflects its longstanding commitment to prioritizing shareholder value. The decision also reflects the company’s response to heightened market volatility driven by increasing geopolitical risks. In fact, Celltrion has continued to implement shareholder-friendly initiatives in 2024 and 2025, including treasury share purchases and cancellations, as well as providing updates to shareholders on the company’s response to rapidly changing market conditions. In addition, the company plans to proactively reflect the intent of the amended Commercial Act at this year’s shareholders’ meeting by introducing measures such as an independent director system, mandatory cumulative voting, an increase in separately elected outside directors, and the adoption of electronic shareholder meetings, further strengthening the protection of shareholder rights. Other agenda items to be presented at the shareholders’ meeting include partial amendments to the articles of incorporation, appointment of directors, and approval of financial statements including a cash dividend of KRW 750 per share. The director appointment agenda has been revised to nominate Shin Min-chul, Head of the Administration Unit and President, as an internal director, replacing Kim Hyoung-ki, Vice Chairman and Head of the Global Sales Business Group, who has decided to step down due to personal reasons. In addition, part of the statement of appropriation of retained earnings has been revised to secure surplus for the additional treasury share cancellation. “The decision to cancel 9.11 million treasury shares, representing 74% of the company’s total treasury holdings including the additional amount announced today, reflects our commitment to prioritizing the protection of shareholder interests amid an unstable market environment,” a Celltrion official said. “We will continue to respond to market changes while conducting our business responsibly and enhancing shareholder value, and will make every effort to achieve this year’s revenue target of KRW 5.3 trillion.” [1] Closing price on March 5, KRW 211,500

2026
03
06
Letter to Shareholders [U.S. Manufacturing Operations and Tariff Risk Position]

Dear Valued Shareholders, To address market concerns arising from recent references to changes in U.S. government tariff policies, we would like to share with our shareholders the current operational status of the Branchburg facility and our forward plans as follows. Initiation of CMO Production and Validation for In-House Product Manufacturing Following the successful completion of the acquisition of the former Eli Lilly facility late last year, we finalized a comprehensive inspection of the entire site and completed all preparations for full-scale operations by the end of January this year. Based on these efforts, we commenced full-scale production of Lilly CMO products across all lines beginning in February, thereby demonstrating the operational efficiency of our U.S. manufacturing facility. In parallel, Celltrion has initiated validation procedures required for the manufacturing of its own products. By integrating local manufacturing with its direct commercial network, we plan to establish a fully integrated system capable of supplying locally manufactured products to the U.S. market in due course. Structural Mitigation of Tariff Risks and Completion of Preemptive Measures Celltrion has completed all necessary measures to ensure that its business operations remain unaffected, regardless of how future U.S. tariff issues may unfold. Short-term Response: Sales will continue without tariff impact through the utilization of approximately two years of inventory already positioned within the United States.Mid- to long-term Response: Direct supply of products from the Branchburg manufacturing facility will enable the operation of a production-and-sales system that is fully insulated from tariff-related issues. In conclusion, despite the U.S. Supreme Court’s ruling invalidating reciprocal tariffs and the potential for future changes in tariff policy under the Trump administration, we have established a structurally resilient local production and supply system, ensuring that its operations remain unaffected by tariff-related uncertainties. Celltrion remains focused on closely monitoring local market conditions and making every effort to safeguard shareholder value. We sincerely appreciate our shareholders’ continued trust and support. 

2026
02
25
Letter to Shareholders [Company Statement Regarding U.S. Tariff Response Strategy]

Dear Valued Shareholders,On January 27, 2026 (KST), U.S. President Trump announced plans to restore reciprocal tariffs on South Korean goods to levels prior to the trade agreement.In response, our company has already established a fundamental solution to these tariff concerns by securing the Branchburg production facility in New Jersey, U.S. This strategic move allows us to structurally decouple our operations from such regulatory risks.The Branchburg facility officially commenced operations following an opening ceremony earlier this month, attended by key local and international dignitaries. We intend to utilize this facility as our primary hub for manufacturing products destined for the U.S. market. By integrating this local production with our direct sales network, we plan to accelerate the start of manufacturing to ensure a seamless and efficient product supply.Furthermore, we have finalized a time-phased response strategy to address any uncertainties regarding U.S. tariffs. During the transition period until the U.S. facility reaches full production capacity, we will continue our sales operations without any tariff impact, utilizing the two-year supply of inventory already stationed within the United States.By preparing comprehensive short-term and long-term response systems on the ground in the U.S., we are positioned to ensure that our business remains unaffected by any changes in tariff policy.We remain committed to closely monitoring local market conditions and ensuring the stable operation of our business. We will continue to provide updates to our shareholders to maintain your trust and support.Thank you. 

2026
01
27
Letter to Shareholders [Statement on the Request to Convene an Extraordinary General Meeting of Shareholders]

Dear valued shareholders, Celltrion, Inc. (“The Company”) hereby provides a detailed explanation to our shareholders regarding the current status of, and the Company’s clear position on, the recently submitted request to convene an Extraordinary General Meeting of Shareholders (“EGM”). While the Company remains firmly committed to listening attentively to the valuable opinions of our shareholders and is reviewing this matter with due responsibility, the review and decision-making process concerning a request to convene an EGM must be conducted fairly and transparently in strict accordance with applicable legal procedures, as it directly affects the rights and interests of all shareholders. Recently, the “Celltrion Minority Shareholders Special Committee” (the “Committee”) submitted a request to convene an EGM with agenda items including, among others: (i) reduction of capital (cancellation of treasury shares), (ii) removal of directors, and (iii) amendments to the Articles of Incorporation, together with other advisory shareholder proposals. To hear and understand the position of minority shareholders, the Company held a meeting with representatives of the Committee on December 2. At the meeting held for more than one hour, the Company provided the following clarifications: The Company is willing to proceed without delay with the procedures to convene an EGM if a request is duly submitted in compliance with applicable laws.However, the present request to convene an EGM does not satisfy the statutory requirements, as it lacks the basic supporting documents required under relevant laws and precedents.If the Company were to accept the request without conducting a reasonable legal review of the statutory requirements, it could give rise to issues such as a violation of the principle of shareholder equality.Nevertheless, in respect of the intentions of the shareholders who submitted the request, the Company is reviewing the possibility of voluntarily submitting to the next Annual General Meeting of Shareholders any legally permissible agenda items included in the request, such as the cancellation of treasury shares and the adoption of cumulative voting. Under the current Korean Commercial Act, shareholders who hold no less than 3 percent of the total number of issued and outstanding shares, or any person who has continued to hold stocks equivalent to no less than 1.5 percent of the total number of issued and outstanding shares of a listed company for more than six months may request convocation of an EGM. In addition, pursuant to the Act on Electronic Registration of Stocks and Bonds, objective evidentiary documents—such as certificate of ownership issued by the Korea Securities Depository—are required to substantiate that these statutory requirements have been met. However, the Committee claimed that it had received proxies from shareholders representing 1.71% of the total number of issued shares, and submitted as supporting documents only two shareholder lists and proxy forms as of two specific record dates, March 31 and September 30 of this year. Based solely on these materials, the Company was unable to verify whether the relevant shareholders satisfied the requirement of “continuous ownership for six months or longer” as of the date of the request to convene the EGM. Accordingly, both before and after the meeting, the Company repeatedly requested that the Committee submit materials—such as certificates of ownership—capable of verifying compliance with the statutory requirements. However, even as of the date on which the Company received service of a copy of the petition for court permission to convene an EGM, no additional supporting documents had been provided.Therefore, the Committee’s assertion that the Company unreasonably refused the request and failed to respect shareholders’ intentions is inconsistent with the facts. The Company will respond faithfully to the court proceedings concerning the request to convene an EGM in accordance with the law and established principles, and if the Committee supplements the request with the requisite basic supporting documents, the Company intends to proceed without delay with the procedures to convene an EGM. As the convening of an EGM directly affects the rights and interests of all shareholders, it is of paramount importance for the Company to accurately confirm compliance with the statutory requirements. The shareholder lists and proxy forms submitted by the Committee alone are insufficient to demonstrate that the legal requirements for requesting an EGM have been satisfied, making it difficult for the Company to proceed with the convening procedures. The Company has already communicated this position to the Committee on multiple occasions and has reiterated that such verification is an essential measure to ensure the legitimacy of the shareholders’ meeting. The Company places the highest priority on enhancing shareholder value and achieving sustainable growth together with our shareholders, and is making every effort to increase corporate value in pursuit of these objectives. Taking into account treasury share purchases and cancellations, cash dividends, and other shareholder return measures, the Company’s shareholder return ratio for this year is expected to significantly exceed—by several times—the three-year average target of 40% through 2027 presented in the Company’s value-up program announced earlier this year. The Company remains committed to further enhancing shareholder value through measures such as tax-exempt dividends and cash dividends going forward. We sincerely appreciate our shareholders’ continued trust and support. 

2025
12
18
Letter to Shareholders [Update on the Acquisition of Eli Lilly’s U.S. Manufacturing Facility]

Dear Valued Shareholders, On September 20 (local time), Celltrion entered into an agreement with global pharmaceutical company Eli Lilly to acquire its U.S. manufacturing facility. We have completed all required regulatory procedures related to the acquisition. We would like to take this opportunity to promptly share with our shareholders the details and progress of this important development. Following approval from Ireland’s Competition and Consumer Protection Commission (CCPC) last month, Celltrion has recently completed the “business combination” review process conducted by the Premerger Notification Office (PNO) of the U.S. Federal Trade Commission (FTC). The “business combination” review is a process to assess whether a merger or asset acquisition could potentially hinder market competition. Celltrion is to undergo regulatory reviews under the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) in the United States and by the relevant authorities in Ireland due to exceeding certain local revenue thresholds. Upon deal closing, Celltrion plans to accelerate post-merger integration (PMI) by dispatching key personnel across various business areas to ensure a seamless transition with no disruption to operations. We will also provide tailored support to help existing local employees adapt quickly to organizational changes, taking into account regional characteristics. Through this acquisition, Celltrion secures multiple strategic advantages: elimination of tariff-related risks, mitigation of geopolitical uncertainties through manufacturing site diversification, and expansion of contract manufacturing (CMO) opportunities within the United States. In particular, the CMO business will be actively expanded around the Branchburg facility, leveraging the growing demand for pharmaceutical production in the U.S. Given the growing demand for CMO services in the U.S, Celltrion plans to utilize its extensive track record in biopharmaceutical development, manufacturing, and new drug CMO projects to attract new clients. Under the previously agreed CMO contract with Eli Lilly, revenue generation will begin immediately upon acquisition, allowing for early recovery of investment. Going forward, Celltrion will continue to pursue top-tier business performance while implementing shareholder-friendly policies to enhance shareholder value. We also remain committed to maintaining transparent and consistent communication regarding the company’s business plans and outlook. We sincerely thank all our shareholders for your continued trust and support for Celltrion.

2025
11
11