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Vol013. Demystifying Antibodies, exploring Their Remarkable NatureAntibodies are proteins produced by our immune system. They fight against antigens, foreign substances that enter our body, such as bacteria, viruses, fungi, and various other toxins. -
Vol012. What is Antibody-Drug Conjugate?Antibody-Drug Conjugates (ADCs) are highly targeted biopharmaceuticals built by combining a potent small molecule drug with an antibody that binds to specific types of antigens. -
Vol011. How mRNA Vaccine WorksThe most traditional type of vaccines are either inactivated vaccine or attenuated vaccine; introducing human body with killed virus or the weakened in its force through a series of subculture. -
Vol010. How to Diagnose Covid-19Preventing and treating COVID-19 is not easy because of the speed of viral spread and high possibility of asymptomatic cases. Thus the key to an effective treatment starts with quick and accurate diagnosis of infection. -
Vol009. Biosimilar Production Process 4 Fill&Finish ProcessWhen cell culture fluid passes through multiple purification steps like chromatography, impurities are filtered out leaving only pure antibodies and injection buffers. This is called drug substance (DS). Fill & finish is the process through which the DS is filled into containers, labeled and packaged to be a finished drug product (DP). -
Vol008. Global Pandemic Corona Virus Disease-19Coronavirus Disease-19 (COVID-19) is a respiratory illness caused by a strain of oronavirus named “severe acute respiratory syndrome coronavirus2 (SARS-CoV-2)”. Symptoms of COVID-19 varies from coughing and a fever to much severe ones as dyspnea (shortness of breath), and in some cases, severe respiratory infections such as pneumonia. -
Vol007. Biosimilar Production Process3 Purification ProcessThe culture fluid completed 15 days of cell culture process contains antibodies that will become the active ingredients for finished pharmaceutical products, mixed up with other components such as cell debris, bacteria, and leftover media. Purification is the process of removing these impurities to obtain pure antibodies and making into an active pharmaceutical ingredient. -
Vol006. Biosimilar Production Process2 Cell Culture ProcessCell culture is the process by which a cell line grows and proliferates to mass-produce antibodies, the source material for biosimilar products. The productivity and quality of a cell line may largely vary depending on the culturing technique and environment. Thus developing and providing optimal condition for cells are necessary to make competitive product. -
Vol005. Biosimilar Production Process1 Cell Line DevelopmentBiosimilar production first starts with developing cell lines, the permanently established cell culture that generates the base material for biosimilar medicine:recombinant antibodies protein. -
Vol003. What is Inflammatory Bowel Disease?The intestines can be described as a ‘sewage treatment system’ of our body. Just as a city suffers from wastewater overflow and toxic odor when sewage system malfunctions, chronic intestines inflammation can cause abdominal pain, diarrhea, weight loss, and many other sickness. These phenomena are named as “inflammatory bowel disease (IBD).” -
Vol002. Treatment of Rheumatoid ArthritisExact triggers of rheumatoid arthritis are not completely known, but the main cause seems to be the autoimmune reaction that occurs in the synovial joint. This autoimmune reaction in the joint synovium produces neurotransmitters like TNF-α and interleukin-1 that promote inflammation by producing antigen-presenting cells (APCs). -
Vol001. What is Rheumatoid Arthritis?“Rheumatoid arthritis” is a type of autoimmune disorder, that abnormal autoimmune functions of a patients cause chronic and systemic inflammation. The diseases typically results in inflammation in the joint synovium and symmetric swelling in multiple and hand and foot joints. Patients experience severe pain in affected areas, and the pain grows intense as the disease progresses.
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Introducing Celltrion’s biological and generic pharmaceutical products
